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Bioorthogonal metabolic glycoengineering of human larynx carcinoma (HEp-2) cells targeting sialic acid.

Homann, Arne
; 
Qamar, Riaz-Ul
; 
Serim, Sevnur
; 
Dersch, Petra
; 
Seibel, Jürgen
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2010
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Abstract
Sialic acids are located at the termini of mammalian cell-surface glycostructures, which participate in essential interaction processes including adhesion of pathogens prior to infection and immunogenicity. Here we present the synthesis and bioorthogonal metabolic incorporation of the sialic acid analogue N-(1-oxohex-5-ynyl)neuraminic acid (Neu5Hex) into the cell-surface glycocalyx of a human larynx carcinoma cell line (HEp-2) and its fluorescence labelling by click chemistry.
Citation
Bioorthogonal metabolic glycoengineering of human larynx carcinoma (HEp-2) cells targeting sialic acid. 2010, 6:24 Beilstein J Org Chem
Affiliation
University of Würzburg, Department of Organic Chemistry, Am Hubland, 97074 Würzburg, Germany.
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Journal
Beilstein journal of organic chemistry
URI
http://hdl.handle.net/10033/118667
DOI
10.3762/bjoc.6.24
PubMed ID
20502611
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Article
Language
en
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1860-5397
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publications of the work group of molecular Infectionbiology (MIBI)