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Early changes in the metabolic profile of activated CD8(+) T cells.
Cammann, Clemens Rath, Alexander Reichl, Udo Lingel, Holger Brunner-Weinzierl, Monika Simeoni, Luca Schraven, Burkhart Lindquist, Jonathan A
Cammann, Clemens
Rath, Alexander
Reichl, Udo
Lingel, Holger
Brunner-Weinzierl, Monika
Simeoni, Luca
Schraven, Burkhart
Lindquist, Jonathan A
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Abstract
Antigenic stimulation of the T cell receptor (TCR) initiates a change from a resting state into an activated one, which ultimately results in proliferation and the acquisition of effector functions. To accomplish this task, T cells require dramatic changes in metabolism. Therefore, we investigated changes of metabolic intermediates indicating for crucial metabolic pathways reflecting the status of T cells. Moreover we analyzed possible regulatory molecules required for the initiation of the metabolic changes.
Citation
Early changes in the metabolic profile of activated CD8(+) T cells. 2016, 17 (1):28 BMC Cell Biol.
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Journal
PubMed ID
PubMed Central ID
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Article
Language
en
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Series/Report no.
ISSN
1471-2121