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Host-pathogen interactions in streptococcal immune sequelae.

Nitsche-Schmitz, D Patric
; 
Chhatwal, Gursharan S
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2013
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Abstract
Otherwise uncomplicated infections with Streptococcus pyogenes can cause two insidious immune sequelae known as post-streptococcal glomerulonephritis (PSGN) and acute rheumatic fever (ARF). These diseases follow with a latency of a few weeks or months after primary infection and are responsible for high mortality and morbidity. PSGN has also been linked to infections with group C streptococci of the species S. equi ssp. zooepidemicus (SESZ). Moreover, there are some indications that infection with group C and G streptococci (GCGS) of the subspecies Streptococcus dysgalactiae ssp. equisimilis (SDSE) leads to ARF. Despite decades of research, the picture of the molecular pathogenesis of streptococcal immune sequelae resembles a jigsaw puzzle. Herein we try to put some of the puzzle bits together that have been collected till date.
Citation
Host-pathogen interactions in streptococcal immune sequelae. 2013, 368:155-71 Curr. Top. Microbiol. Immunol.
Affiliation
Helmholtz Centre for Infection Research, Inhoffenstraße 7, D-38124 Braunschweig, Germany. Patric.Nitsche@helmholtz-hzi.de
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Journal
Current topics in microbiology and immunology
URI
http://hdl.handle.net/10033/297472
DOI
10.1007/82_2012_296
PubMed ID
23212184
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Book chapter
Language
en
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0070-217X
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Archived with thanks to Current topics in microbiology and immunology
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Publications of Dept. Medizinische Mikrobiologie (MMIK)