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MATHEMATISCHE BEHANDLUNG VON SINGLE-CELL-PROTEIN-PROZESSEN
Luttmann, R. Buchholz, H. Munack, A. Scheiding, W. Zakrzewski, W. Thoma, M. Schügerl, K. Wagner, F
Luttmann, R.
Buchholz, H.
Munack, A.
Scheiding, W.
Zakrzewski, W.
Thoma, M.
Schügerl, K.
Wagner, F
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1982
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2022-12-08
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Abstract
Hansenula polymorpha fed-batch cultivations were carried out on ethanol-substrate in a cocurrent 275 cm high bubble column loop bioreactor. The studied single-cell-protein-( SCP-) processes are time- and spacedependent. The mathematical description leads to a set of coupled nonlinear partial differential equations (distributed parameter system). The model equations contain X-, S-, and 0,- balances in the liquid phases of column and loop as well as 0,-, No- (inert) and C0, - balances in the gas phase of the reactor. Nonstationary model equations have been solved and unknow parameters, volumetric mass transfer coefficient ky +a, 0,- and Syield coefficients, Yyyo and Yyys> 0,- and S-saturation constants, Ko and Ko» have been identified -by fast hybrid simulation methods. Some identified parameters depend strongly on the process conditions, classified into unlimited growth, oxygen transferand substrate-limited growth. The time dependence of parameters during the dynamical processes needs adaptive control strategies. Based on excellent agreement of experiments and mathematical model on-line control algorithmen (OLFO=Open Loop Feedback Optimal Control) have been developed for optimal control of batch processes in tower reactors.
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Mikrobielle Proteingewinnung und Biotechnologie, 2. Symposium, 1980, 27-38
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conference paper
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de
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Attribution-NonCommercial-ShareAlike 4.0 International