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Antifungal Sesquiterpenoids, Rhodocoranes, from Submerged Cultures of the Wrinkled Peach Mushroom, Rhodotus palmatus.
Sandargo, Birthe Michehl, Maira Surup, Frank
Sandargo, Birthe
Michehl, Maira
Surup, Frank
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2019-12-10
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Abstract
Seven previously unknown sesquiterpenoids and norsesquiterpenoids, rhodocoranes F-L (1-7), were isolated from the fermentation broth of the basidiomycete Rhodotus palmatus. Their structures were elucidated utilizing 1D and 2D NMR techniques as well as HRESIMS; they are unusual noracorane, spiro[4.4]nonene, and acorane-type sesquiterpenoids. They include the first naturally occurring cyclopentylidenefuranones (3-5) and the new tricyclic scaffold of 7. Metabolites 1-7 exhibited a general mild antimycotic activity, while 1-3 also displayed cytotoxic effects.
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J Nat Prod. 2019 Dec 10. doi: 10.1021/acs.jnatprod.9b00871
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en
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1520-6025
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Attribution-NonCommercial-ShareAlike 4.0 International