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Homologous recombination mediates stable Fah gene integration and phenotypic correction in tyrosinaemia mouse-model.

Junge, Norman
; 
Yuan, Qinggong
; 
Vu, Thu Huong
; 
Krooss, Simon
; 
Bednarski, Christien
; 
Balakrishnan, Asha
; 
Cathomen, Toni
; ; 
Baumann, Ulrich
; 
Sharma, Amar Deep
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2018-02-27
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Abstract
To stably correct tyrosinaemia in proliferating livers of fumarylacetoacetate-hydrolase knockout (Fah-/-)mice by homologous-recombination-mediated targeted addition of theFahgene.
Citation
Homologous recombination mediates stable Fah gene integration and phenotypic correction in tyrosinaemia mouse-model. 2018, 10 (2):277-286 World J Hepatol
Affiliation
TWINCORE, Zentrum für experimentelle und klinischeInfektionsforschung GmbH, Feodor-Lynen-Str. 7, 30625 Hannover, Germany.
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World journal of hepatology
URI
http://hdl.handle.net/10033/621336
DOI
10.4254/wjh.v10.i2.277
PubMed ID
29527263
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en
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1948-5182
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