Loading...
Regulatory T cells control endothelial chemokine production and migration of T cells into intestinal tumors of APC mice.
Akeus, Paulina Szeponik, Louis Ahlmanner, Filip Sundström, Patrik Alsén, Samuel Gustavsson, Bengt Raghavan, Sukanya Quiding-Järbrink, Marianne
Akeus, Paulina
Szeponik, Louis
Ahlmanner, Filip
Sundström, Patrik
Alsén, Samuel
Gustavsson, Bengt
Raghavan, Sukanya
Quiding-Järbrink, Marianne
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
2018-04-18
Submitted date
Files
Loading...
Open Access article
Adobe PDF, 1.64 MB
Other Titles
Abstract
Tumor-infiltrating lymphocytes are crucial for anti-tumor immunity. We have previously shown that regulatory T cells (Treg) are able to reduce T-cell transendothelial migration in vitro and accumulation of effector T cells in intestinal tumors in vivo. Treg depletion also resulted in increased levels of the chemokines CXCL9 and CXCL10 specifically in the tumors. In this study, we investigated the mechanisms for Treg mediated suppression of T-cell migration into intestinal tumors in the APC
Citation
Publisher
Journal
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Article
Language
Description
Series/Report no.
ISSN
1432-0851
EISSN
ISBN
ISMN
Gov't Doc #
Sponsors
License
Attribution-NonCommercial-ShareAlike 3.0 United States