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Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling.
Fava, E Dehghany, J Ouwendijk, J Müller, A Niederlein, A Verkade, P Meyer-Hermann, M Solimena, M
Fava, E
Dehghany, J
Ouwendijk, J
Müller, A
Niederlein, A
Verkade, P
Meyer-Hermann, M
Solimena, M
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2012-04
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Abstract
Knowledge of number, size and content of insulin secretory granules is pivotal for understanding the physiology of pancreatic beta cells. Here we re-evaluated key structural features of rat beta cells, including insulin granule size, number and distribution as well as cell size.
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Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling. 2012, 55 (4):1013-23 Diabetologia
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en
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1432-0428
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