Loading...
TRANSDUCTION OF THE CHEMORECEPTOR-EFFECTOR INTERACTION AT LANGMUIRBLODGETT FILMS AND MEMBRANES
Thompson, M.
Thompson, M.
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
1987
Submitted date
2023-08-30
Files
Loading...
PDF
Adobe PDF, 3.63 MB
Other Titles
Abstract
Biological organisms respond to chemical messages internally and externally through a variety of receptor cells. The chemoreceptive process at membranes offers an interesting model for the development of biosensors. In the present paper, we discuss briefly molecular recognition provided by receptors in the context of sensor design. Work in our laboratory has been concerned with perturbation of ionic fluxes through bilayer lipid membranes by selective bimolecular interactions. As a model for this process we have performed experiments with a Langmuir-Blodgett film balance in which reagents are infused into the subphase. The surface pressure and area characteristics and dipole potential are all monitored concurrently. In the case of lectin-polysaccharide and immunochemical bimolecular interactions interesting transients in potential were observed. These are attributed to perturbation of the monolayer dipole structure by surface aggregative processes. Partial confirmation of this result was obtained from Langmuir-Blodgett fluorescence microscope experiments performed at the Technische Universitat, MUnchen.
Citation
Biosensors International Workshop 1987, 145 - 150
DOI
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Book chapter
conference paper
conference paper
Language
en
Description
Series/Report no.
GBF Monographs, Volume 10
ISSN
0930-4320
EISSN
ISBN
0-89573-683-7
3-527-26801-4
3-527-26801-4
ISMN
Gov't Doc #
Sponsors
License
Attribution-NonCommercial-ShareAlike 4.0 International