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Triazole-based cross-linkers in radical polymerization processes: tuning mechanical properties of poly(acrylamide) and poly( -dimethylacrylamide) hydrogels
Götz, Tobias Schädel, Nicole Petri, Nadja Kirchhof, Manuel Bilitewski, Ursula Tovar, Günter E. M. Laschat, Sabine Southan, Alexander
Götz, Tobias
Schädel, Nicole
Petri, Nadja
Kirchhof, Manuel
Bilitewski, Ursula
Tovar, Günter E. M.
Laschat, Sabine
Southan, Alexander
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Abstract
Triazole-based cross-linkers with different spacer lengths and different functional end groups (acrylamides, methacrylamides, maleimides and vinylsulfonamides) were synthesized, investigated for cytotoxic and antibacterial activity, and incorporated into poly(acrylamide) (PAAm) and poly(N,N-dimethylacrylamide) (PDMAAm) hydrogels by free-radical polymerization. Hydrogels prepared with different cross-linkers and cross-linker contents between 0.2% and 1.0% were compared by gel yields, equilibrium degrees of swelling (S) and storage moduli (G0). Generally with increasing cross-linker content, G0 values of the hydrogels increased, while S values decreased. The different polymerizable cross-linker end groups resulted in a decrease of G0 in the following order for cross-linkers with C4 spacers: acrylamide > maleimide > methacrylamide > vinylsulfonamide. Longer cross-linker alkyl spacer lengths caused an increase in G0 and a decrease in S. Independent of the cross-linker used, a universal correlation between G0 and equilibrium polymer volume fraction f was found. For PAAm hydrogels, G0 ranged between 4 kPa and 23 kPa and f between 0.07 and 0.14. For PDMAAm hydrogels, G0 ranged between 0.1 kPa and 4.9 kPa and f between 0.02 and 0.06. The collected data were used to establish an empirical model to predict G0 depending on f. G0 of PAAm and PDMAAm hydrogels is given by G0 ¼ 4034 kPa f2.66 and G0 ¼ 4297 kPa f2.46, respectively.
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2046-2069
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Attribution-NonCommercial-ShareAlike 3.0 United States