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Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections.
Bergsten, Helena Madsen, Martin Bruun Bergey, Francois Hyldegaard, Ole Skrede, Steinar Arnell, Per Oppegaard, Oddvar Itzek, Andreas Perner, Anders Svensson, Mattias
Bergsten, Helena
Madsen, Martin Bruun
Bergey, Francois
Hyldegaard, Ole
Skrede, Steinar
Arnell, Per
Oppegaard, Oddvar
Itzek, Andreas
Perner, Anders
Svensson, Mattias
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2020-01-09
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Abstract
Analyses of plasma collected pre- and post-administration of intravenous immunoglobulin G (IVIG) from patients with Group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r=-0.67, p<0.0001). One 25g-dose IVIG was sufficient to yield patient plasma neutralizing activity against streptococcal superantigens.
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Clin Infect Dis. 2020 Jan 9. pii: 5698680. doi: 10.1093/cid/ciaa022.
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en
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1537-6591
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Attribution-NonCommercial-ShareAlike 4.0 International