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Expression and Activity of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Distal Lung Epithelial Cells In Vitro.

Nickel, Sabrina
; 
Selo, Mohammed Ali
; 
Fallack, Juliane
; 
Clerkin, Caoimhe G
; 
Huwer, Hanno
; 
Schneider-Daum, Nicole
; ; 
Ehrhardt, Carsten
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Issue Date
2017-05-03
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Abstract
Breast cancer resistance protein (BCRP/ABCG2) has previously been identified with high expression levels in human lung. The subcellular localisation and functional activity of the transporter in lung epithelia, however, remains poorly investigated. The aim of this project was to study BCRP expression and activity in freshly isolated human alveolar epithelial type 2 (AT2) and type 1-like (AT1-like) cells in primary culture, and to compare these findings with data obtained from the NCI-H441 cell line.
Citation
Expression and Activity of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Distal Lung Epithelial Cells In Vitro. 2017 Pharm. Res.
Affiliation
Helmholtz Institut für Pharmaceutischr Forschung Saarland, Universitätscampus E8.1, 66123 Saarbrücken, Germany.
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Journal
Pharmaceutical research
URI
http://hdl.handle.net/10033/620926
DOI
10.1007/s11095-017-2172-9
PubMed ID
28470471
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Article
Language
en
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ISSN
1573-904X
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publications of the research group drug delivery ([HIPS] DDEL)