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Beware the intruder: Real time observation of infiltrated neutrophils and neutrophil-Microglia interaction during stroke in vivo.
Neumann, Jens Henneberg, Sophie von Kenne, Susanne Nolte, Niklas Müller, Andreas J Schraven, Burkhart Görtler, Michael W Reymann, Klaus G Gunzer, Matthias Riek-Burchardt, Monika
Neumann, Jens
Henneberg, Sophie
von Kenne, Susanne
Nolte, Niklas
Müller, Andreas J
Schraven, Burkhart
Görtler, Michael W
Reymann, Klaus G
Gunzer, Matthias
Riek-Burchardt, Monika
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Abstract
Inflammation plays an important role in the pathogenesis of ischemic stroke including an acute and prolonged inflammatory process. The role of neutrophil granulocytes as first driver of the immune reaction from the blood site is under debate due to controversial findings. In bone marrow chimeric mice we were able to study the dynamics of tdTomato-expressing neutrophils and GFP-expressing microglia after photothrombosis using intravital two-photon microscopy. We demonstrate the infiltration of neutrophils into the brain parenchyma and confirm a long-lasting contact between neutrophils and microglia as well as an uptake of neutrophils by microglia clearing the brain from peripheral immune cells.
Citation
Beware the intruder: Real time observation of infiltrated neutrophils and neutrophil-Microglia interaction during stroke in vivo. 2018, 13 (3):e0193970 PLoS ONE
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PubMed ID
PubMed Central ID
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Article
Language
en
Description
Series/Report no.
ISSN
1932-6203