Loading...
Itaconic acid indicates cellular but not systemic immune system activation.
Meiser, Johannes Kraemer, Lisa Jaeger, Christian Madry, Henning Link, Andreas Lepper, Philipp M Hiller, Karsten Schneider, Jochen G
Meiser, Johannes
Kraemer, Lisa
Jaeger, Christian
Madry, Henning
Link, Andreas
Lepper, Philipp M
Hiller, Karsten
Schneider, Jochen G
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
2018-08-14
Submitted date
Files
Loading...
Open Access publication
Adobe PDF, 1.58 MB
Other Titles
Abstract
Itaconic acid is produced by mammalian leukocytes upon pro-inflammatory activation. It appears to inhibit bacterial growth and to rewire the metabolism of the host cell by inhibiting succinate dehydrogenase. Yet, it is unknown whether itaconic acid acts only intracellularly, locally in a paracrine fashion, or whether it is even secreted from the inflammatory cells at meaningful levels in peripheral blood of patients with severe inflammation or sepsis. The aim of this study was to determine the release rate of itaconic acid from pro-inflammatory activated macrophages
Citation
Publisher
Journal
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Article
Language
Description
Series/Report no.
ISSN
1949-2553
EISSN
ISBN
ISMN
Gov't Doc #
Sponsors
License
Attribution-NonCommercial-ShareAlike 3.0 United States