Merging bioresponsive release of insulin-like growth factor I with 3D printable thermogelling hydrogels
Beudert, Matthias Hahn, Lukas Horn, Anselm H.C. Hauptstein, Niklas Sticht, Heinrich Meinel, Lorenz Luxenhofer, Robert Gutmann, Marcus Lühmann, Tessa
Beudert, Matthias
Hahn, Lukas
Horn, Anselm H.C.
Hauptstein, Niklas
Sticht, Heinrich
Meinel, Lorenz
Luxenhofer, Robert
Gutmann, Marcus
Lühmann, Tessa
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Issue Date
2022-07-01
Submitted date
2021-11-30
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Abstract
3D printing of biomaterials enables spatial control of drug incorporation during automated manufacturing. This study links bioresponsive release of the anabolic biologic, insulin-like growth factor-I (IGF-I) in response to matrix metalloproteinases (MMP) to 3D printing using the block copolymer of poly(2-methyl-2-oxazoline) and thermoresponsive poly(2-n-propyl-2-oxazine) (POx-b-POzi). For that, a chemo-enzymatic synthesis was deployed, ligating IGF-I enzymatically to a protease sensitive linker (PSL), which was conjugated to a POx-b-POzi copolymer. The product was blended with the plain thermogelling POx-b-POzi hydrogel. MMP exposure of the resulting hydrogel triggered bioactive IGF-I release. The bioresponsive IGF-I containing POx-b-POzi hydrogel system was further detailed for shape control and localized incorporation of IGF-I via extrusion 3D printing for future applications in biomedicine and biofabrication. © 2022 Elsevier B.V.
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en
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Vol. 377, July 2022
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01683659
EISSN
18734995
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Deutsche Forschungsgemeinschaft
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Attribution-NonCommercial 4.0 International