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Composing compound libraries for hit discovery--rationality-driven preselection or random choice by structural diversity?

Weidel, Elisabeth
; 
Negri, Matthias
; 
Empting, Martin
; 
Hinsberger, Stefan
; 
Hartmann, Rolf W
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2014
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Abstract
In order to identify new scaffolds for drug discovery, surface plasmon resonance is frequently used to screen structurally diverse libraries. Usually, hit rates are low and identification processes are time consuming. Hence, approaches which improve hit rates and, thus, reduce the library size are required.
Citation
Composing compound libraries for hit discovery--rationality-driven preselection or random choice by structural diversity? 2014, 6 (18):2057-72 Future Med Chem
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Journal
Future medicinal chemistry
URI
http://hdl.handle.net/10033/345823
DOI
10.4155/fmc.14.142
PubMed ID
25531968
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Article
Language
en
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ISSN
1756-8927
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publications of the research group drug design and optimization(HIPS]DDOP)