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BATCH INJECTION ANALYSIS FOR HIGH-SPEED BIOSENSING
Wang, Joseph Wu, Li-Huey Chen, Liang Taha, Ziad
Wang, Joseph
Wu, Li-Huey
Chen, Liang
Taha, Ziad
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Issue Date
1992
Submitted date
2024-05-08
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Abstract
The principles of a new, non-flow, injection technique, termed batch injection analysis (BIA), for high speed biosensing are described. BIA is based on the reproducible injection of small samples toward a nearby detector, which is immersedin a large-volume stirred bulk solution. Passage of the sample zone over the detector surface results in sharp peak readouts, similar to those of flow injection analysis (FIA). Sample throughputs and size, the sensitivity, detection limits and reproducibility, are also similar to those of FIA. In addition, the need for pumps and connecting tubingsis eliminated. Becauseof the limited solution handling capability, BIA relies on the use of specific or reactive sensing surfaces. In particular, the inherent specificity of biosensors makes them extremely attractive for the BIA operation. Such characteristics and advantagesareillustrated for the use of enzymes or tissues, coupled to amperometric, potentiometric or thermal BIA detectors. The high-speed and simple BlA/biosensing operation holds a great promisefor clinical screening and bioprocess monitoring.
Citation
Biosensors : fundamentals, technologies and applications, 461 - 466
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Type
Book chapter
conference paper
conference paper
Language
en
Description
Series/Report no.
GBF monographs ; Volume 17
ISSN
0930-4320
EISSN
ISBN
1560812206
3527284370
3527284370
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Attribution-NonCommercial-ShareAlike 4.0 International