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Immunization with live virus vaccine protects highly susceptible DBA/2J mice from lethal influenza A H1N1 infection.

Dengler, Leonie
; 
May, Mathias
; ; 
Bahgat, Mahmoud M
; 
Schughart, Klaus
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2012
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Abstract
The mouse represents an important model system to study the host response to influenza A infections and to evaluate new prevention or treatment strategies. We and others reported that the susceptibility to influenza A virus infections strongly varies among different inbred mouse strains. In particular, DBA/2J mice are highly susceptible to several influenza A subtypes, including human isolates and exhibit severe symptoms after infection with clinical isolates.
Citation
Immunization with live virus vaccine protects highly susceptible DBA/2J mice from lethal influenza A H1N1 infection. 2012, 9:212 Virol. J.
Affiliation
Department of Infection Genetics, Helmholtz Centre for Infection Research and University of Veterinary Medicine Hannover, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
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Journal
Virology journal
URI
http://hdl.handle.net/10033/288579
DOI
10.1186/1743-422X-9-212
PubMed ID
22992381
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Article
Language
en
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1743-422X
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Archived with thanks to Virology journal
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publications of the research group infection genetics (INFG)