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Advances in cytomegalovirus (CMV) biology and its relationship to health, diseases, and aging.

Nikolich-Žugich, Janko
; 
Čicin-Šain, Luka
; 
Collins-McMillen, Donna
; 
Jackson, Sarah
; 
Oxenius, Annette
; 
Sinclair, John
; 
Snyder, Christopher
; 
Wills, Mark
; 
Lemmermann, Niels
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Issue Date
2020-03-11
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Abstract
The complexity of host-associated microbial ecosystems requires host-specific reference catalogs to survey the functions and diversity of these communities. We generate a comprehensive resource, the integrated mouse gut metagenome catalog (iMGMC), comprising 4.6 million unique genes and 660 metagenome-assembled genomes (MAGs), many (485 MAGs, 73%) of which are linked to reconstructed full-length 16S rRNA gene sequences. iMGMC enables unprecedented coverage and taxonomic resolution of the mouse gut microbiota; i.e., more than 92% of MAGs lack species-level representatives in public repositories (<95% ANI match). The integration of MAGs and 16S rRNA gene data allows more accurate prediction of functional profiles of communities than predictions based on 16S rRNA amplicons alone. Accompanying iMGMC, we provide a set of MAGs representing 1,296 gut bacteria obtained through complementary assembly strategies. We envision that integrated resources such as iMGMC, together with MAG collections, will enhance the resolution of numerous existing and future sequencing-based studies.
Citation
Geroscience. 2020 Mar 11. pii: 10.1007/s11357-020-00170-8. doi: 10.1007/s11357-020-00170-8.
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Publisher
Springer
Journal
GeroScience
URI
http://hdl.handle.net/10033/622221
DOI
10.1007/s11357-020-00170-8
PubMed ID
32162210
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Article
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Language
en
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2509-2723
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Attribution-NonCommercial-ShareAlike 4.0 International
cbn
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research group of viral immunology (VIRI)