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NEw MODIFIED ELECTRODES FOR ELECTROCATALYTIC OXIDATION OF NADH BASED ON CONDUCTING POLYMERS
Cooper, J. C. Schuhmann, W. Schmidt, H.-L.
Cooper, J. C.
Schuhmann, W.
Schmidt, H.-L.
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Issue Date
1992
Submitted date
2024-04-10
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Abstract
The dehydrogenases are an importantclass of oxidoreductase enzymes, which depend on the cofactors B-nicotinamide adenine dinucleotide (NAD+)or B-nicotinamide adenine dinucleotide phosphate (NADP+)as electron acceptors. These enzymes catalyse the oxidation of specific substrates, with concomitant production of the reduced cofactor, NAD(P)H. In order to develop amperometric biosensors for determination of such sub- Strates, much researcheffort has been directed towards the electrochemical oxidation of NADH. However, direct oxidation of NADH requires a large overpotential (1) andis thought to involve radical intermediatesthat mayresult in electrode fouling (2).
Citation
Biosensors : fundamentals, technologies and applications, 107 - 110
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Book chapter
conference paper
conference paper
Language
en
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Series/Report no.
GBF monographs ; Volume 17
ISSN
0930-4320
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ISBN
3527284370
1560812206
1560812206
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Attribution-NonCommercial-ShareAlike 4.0 International