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Sepsis induces specific changes in histone modification patterns in human monocytes.
Weiterer, Sebastian Uhle, Florian Lichtenstern, Christoph Siegler, Benedikt H Bhuju, Sabin Jarek, Michael Bartkuhn, Marek Weigand, Markus A
Weiterer, Sebastian
Uhle, Florian
Lichtenstern, Christoph
Siegler, Benedikt H
Bhuju, Sabin
Jarek, Michael
Bartkuhn, Marek
Weigand, Markus A
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Abstract
Sepsis is a global burden and the primary cause of death in intensive care units worldwide. The pathophysiological changes induced by the host's systemic inflammatory response to infection are not yet fully understood. During sepsis, the immune system is confronted with a variety of factors, which are integrated within the individual cells and result in changes of their basal state of responsiveness. Epigenetic mechanisms like histone modifications are known to participate in the control of immune reactions, but so far the situation during sepsis is unknown.
Citation
Sepsis induces specific changes in histone modification patterns in human monocytes. 2015, 10 (3):e0121748 PLoS ONE
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Article
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en
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Series/Report no.
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1932-6203