Loading...
Chronic lung inflammation primes humoral immunity and augments antipneumococcal resistance.
Boehme, Julia D Stegemann-Koniszewski, Sabine Autengruber, Andrea Peters, Nicole Wissing, Josef Jeron, Andreas
Boehme, Julia D
Stegemann-Koniszewski, Sabine
Autengruber, Andrea
Peters, Nicole
Wissing, Josef
Jeron, Andreas
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
2017-07-10
Submitted date
Files
Loading...
Open Access Publication
Adobe PDF, 3.4 MB
Other Titles
Abstract
Airway epithelial cells (AECs) display remarkable plasticity in response to infectious stimuli and their functional adaptations are critical for antimicrobial immunity. However, the roles of AECs and humoral mediators to host defense in non-communicable lung inflammation remain elusive. We dissected pulmonary defense against Streptococcus pneumoniae in hosts with pre-existing inflammatory conditions (SPC-HAxTCR-HA mice). Lung tissue transcriptomics and bronchoalveolar lavage fluid (BALF) proteomics revealed an induction of humoral defense mechanisms in inflamed lungs. Accordingly, besides antibacterial proteins and complement components being overrepresented in inflamed lungs, elevated polymeric immunoglobulin receptor (pIgR)-expression in AECs correlated with increased secretory immunoglobulin (SIg) transport. Consequently, opsonization assays revealed augmented pneumococcal coverage by SIgs present in the BALF of SPC-HAxTCR-HA mice, which was associated with enhanced antipneumococcal resistance. These findings emphasize the immunologic potential of AECs as well as their central role in providing antibacterial protection and put forward pIgR as potential target for therapeutic manipulation in infection-prone individuals.
Citation
Publisher
Journal
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Article
Language
Description
Series/Report no.
ISSN
2045-2322
EISSN
ISBN
ISMN
Gov't Doc #
Sponsors
License
Attribution-NonCommercial-ShareAlike 3.0 United States