Loading...
Attaching and effacing pathogens: the effector ABC of immune subversion.
Riebisch, Anna Katharina Mühlen, Sabrina
Riebisch, Anna Katharina
Mühlen, Sabrina
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
2020-07-27
Submitted date
Files
Loading...
submitted manuscript
Adobe PDF, 361.33 KB
Loading...
figure 1
JPEG, 1.07 MB
Loading...
figure 2
JPEG, 659.99 KB
Loading...
figure 3
JPEG, 1.12 MB
Loading...
Table 1
Adobe PDF, 174.87 KB
Other Titles
Abstract
The innate immune response resembles an essential barrier to bacterial infection. Many bacterial pathogens have, therefore, evolved mechanisms to evade from or subvert the host immune response in order to colonize, survive and multiply. The attaching and effacing pathogens enteropathogenic Escherichia coli, enterohaemorrhagic E. coli, Escherichia albertii and Citrobacter rodentium are Gram-negative extracellular gastrointestinal pathogens. They use a type III secretion system to inject effector proteins into the host cell to manipulate a variety of cellular processes. Over the last decade, considerable progress was made in identifying and characterizing the effector proteins of attaching and effacing pathogens that are involved in the inhibition of innate immune signaling pathways, in determining their host cell targets and elucidating the mechanisms they employ. Their functions will be reviewed here.
Citation
Future Microbiol. 2020 Jul;15:945-958. doi: 10.2217/fmb-2019-0274. Epub 2020 Jul 27.
Publisher
Journal
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Review
Language
en
Description
Series/Report no.
ISSN
EISSN
1746-0921
ISBN
ISMN
Gov't Doc #
Sponsors
License
Attribution-NonCommercial-ShareAlike 4.0 International