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Evolutionary conservation of essential and highly expressed genes in Pseudomonas aeruginosa.

Dötsch, Andreas
; 
Klawonn, Frank
; 
Jarek, Michael
; 
Scharfe, Maren
; 
Blöcker, Helmut
; 
Häussler, Susanne
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2010
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Abstract
The constant increase in development and spread of bacterial resistance to antibiotics poses a serious threat to human health. New sequencing technologies are now on the horizon that will yield massive increases in our capacity for DNA sequencing and will revolutionize the drug discovery process. Since essential genes are promising novel antibiotic targets, the prediction of gene essentiality based on genomic information has become a major focus.
Citation
Evolutionary conservation of essential and highly expressed genes in Pseudomonas aeruginosa. 2010, 11:234 BMC Genomics
Affiliation
Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
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BMC genomics
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http://hdl.handle.net/10033/594416
DOI
10.1186/1471-2164-11-234
PubMed ID
20380691
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Article
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en
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1471-2164
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publications of the research group of molecular bacteriology(MOBA)