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Impact of PEG and PEG-b-PAGE modified PLGA on nanoparticle formation, protein loading and release.
Rietscher, René Czaplewska, Justyna A Majdanski, Tobias C Gottschaldt, Michael Schubert, Ulrich S Schneider, Marc Lehr, Claus-Michael
Rietscher, René
Czaplewska, Justyna A
Majdanski, Tobias C
Gottschaldt, Michael
Schubert, Ulrich S
Schneider, Marc
Lehr, Claus-Michael
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2016-03-16
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Abstract
The effect of modifying the well-established pharmaceutical polymer PLGA by different PEG-containing block-copolymers on the preparation of ovalbumin (OVA) loaded PLGA nanoparticles (NPs) was studied. The used polymers contained poly(d,l-lactic-co-glycolic acid) (PLGA), polyethylene glycol (PEG) and poly(allyl glycidyl ether) (PAGE) as building blocks. The double emulsion technique yielded spherical NPs in the size range from 170 to 220nm (PDI<0.15) for all the differently modified polymers, allowing to directly compare protein loading of and release. PEGylation is usually believed to increase the hydrophilic character of produced particles, favoring encapsulation of hydrophilic substances. However, in this study simple PEGylation of PLGA had only a slight effect on protein release. In contrast, incorporating a PAGE block between the PEG and PLGA units, also eventually enabling active targeting introducing a reactive group, led to a significantly higher loading (+25%) and release rate (+100%), compared to PLGA and PEG-b-PLGA NPs.
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Impact of PEG and PEG-b-PAGE modified PLGA on nanoparticle formation, protein loading and release. 2016, 500 (1-2):187-95 Int J Pharm
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en
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1873-3476