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Fibrosis and Immune Cell Infiltration Are Separate Events Regulated by Cell-Specific Receptor Notch3 Expression.
Brandt, Sabine Ballhause, Tobias M Bernhardt, Anja Becker, Annika Salaru, Delia Le-Deffge, Hien Minh Fehr, Alexander Fu, Yan Philipsen, Lars Djudjaj, Sonja
Brandt, Sabine
Ballhause, Tobias M
Bernhardt, Anja
Becker, Annika
Salaru, Delia
Le-Deffge, Hien Minh
Fehr, Alexander
Fu, Yan
Philipsen, Lars
Djudjaj, Sonja
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2020-08-28
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2019-12-13
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BrandtJASN2020.pdf
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Abstract
Kidney injuries that result in chronic inflammation initiate crosstalk between stressed resident cells and infiltrating immune cells. In animal models, whole-body receptor Notch3 deficiency protects from leukocyte infiltration and organ fibrosis. However, the relative contribution of Notch3 expression in tissue versus infiltrating immune cells is unknown.
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Article
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en
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1533-3450
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Attribution 4.0 International