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Serum microRNA-21 as marker for necroinflammation in hepatitis C patients with and without hepatocellular carcinoma.
Bihrer, Verena Waidmann, Oliver Friedrich-Rust, Mireen Forestier, Nicole Susser, Simone Haupenthal, Jörg Welker, Martin Shi, Ying Peveling-Oberhag, Jan Polta, Andreas
Bihrer, Verena
Waidmann, Oliver
Friedrich-Rust, Mireen
Forestier, Nicole
Susser, Simone
Haupenthal, Jörg
Welker, Martin
Shi, Ying
Peveling-Oberhag, Jan
Polta, Andreas
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Abstract
MicroRNA-21 (miR-21) is up-regulated in tumor tissue of patients with malignant diseases, including hepatocellular carcinoma (HCC). Elevated concentrations of miR-21 have also been found in sera or plasma from patients with malignancies, rendering it an interesting candidate as serum/plasma marker for malignancies. Here we correlated serum miR-21 levels with clinical parameters in patients with different stages of chronic hepatitis C virus infection (CHC) and CHC-associated HCC.
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Serum microRNA-21 as marker for necroinflammation in hepatitis C patients with and without hepatocellular carcinoma. 2011, 6 (10):e26971 PLoS ONE
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en
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1932-6203
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