Loading...
IRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis.
Zhang, Zhenhua Trypsteen, Wim Blaauw, Marc Chu, Xiaojing Rutsaert, Sofie Vandekerckhove, Linos van der Heijden, Wouter Dos Santos, Jéssica Cristina Xu, Cheng-Jian Swertz, Morris A
Zhang, Zhenhua
Trypsteen, Wim
Blaauw, Marc
Chu, Xiaojing
Rutsaert, Sofie
Vandekerckhove, Linos
van der Heijden, Wouter
Dos Santos, Jéssica Cristina
Xu, Cheng-Jian
Swertz, Morris A
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
2021-11-16
Submitted date
Files
Loading...
OPen Access publication
Adobe PDF, 2.18 MB
Other Titles
Abstract
The analysis resulted in one significant association with CA HIV-1 DNA (rs2613996, P < 5 × 10-8) and two suggestive associations with RNA:DNA ratio (rs7113204 and rs7817589, P < 5 × 10-7). Then, we prioritized PTDSS2, IRF7, RNH1, and DEAF1 as potential HIV-1 reservoir modifiers and validated that higher expressions of IRF7 and RNH1 were accompanied by rs7113204-G. Moreover, RNA:DNA ratio, indicating relative HIV-1 transcription activity, was lower in PLHIV carrying this variant.
Citation
BMC Med. 2021 Nov 16;19(1):282. doi: 10.1186/s12916-021-02156-5.
Publisher
Journal
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Article
Language
en
Description
Series/Report no.
ISSN
EISSN
1741-7015
ISBN
ISMN
Gov't Doc #
Sponsors
License
Attribution 4.0 International