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Rickicaryophyllane A, a Caryophyllane from the Ascomyceteous Fungus Hypoxylon rickii and a 10-Norbotryane Congener.
Wiebach, Vincent Surup, Frank Kuhnert, Eric
Wiebach, Vincent
Surup, Frank
Kuhnert, Eric
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2016-07-01
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Abstract
Herein we report the isolation from Hypoxylon rickii of a new sesquiterpenoid (1) with a caryophyllane skeleton. The planar structure of 1 was elucidat ed by NMR and HRMS data as the 1,12-dihydro-l-hydroxyl derivative of caryophyllenol-I, for which we propose the name rickicaryophyllane A. Its relative stereochemistry was assigned with a series of ID NOESY experiments, while the IR,2S,5R,9R absolute configuration was demonstrated by Mosher's analysis. Besides, we isolated 3-(hydroxymethyl)-1,1,3,5-tetramethyl-1,2,3,5,6,7-hexahydro-4H-inden-4-one (2) as a new 10-norbotryane derivative and the known metabolite orcacetophenone (3).
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Nat Prod Commun. 2016 Jul;11(7):909-912.
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en
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1934-578X
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Attribution-NonCommercial-ShareAlike 4.0 International