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IL-7 derived from lymph node fibroblastic reticular cells is dispensable for naive T cell homeostasis but crucial for central memory T cell survival.
Knop, Laura Deiser, Katrin Bank, Ute Witte, Amelie Mohr, Juliane Philipsen, Lars Fehling, Hans J Müller, Andreas J Schüler, Thomas
Knop, Laura
Deiser, Katrin
Bank, Ute
Witte, Amelie
Mohr, Juliane
Philipsen, Lars
Fehling, Hans J
Müller, Andreas J
Schüler, Thomas
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2020-02-11
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Abstract
The survival of peripheral T cells is dependent on their access to peripheral lymph nodes (pLNs) and stimulation by Interleukin-7 (IL-7). In pLNs fibroblastic reticular cells (FRCs) and lymphatic endothelial cells (LECs) produce IL-7 suggesting their contribution to the IL-7-dependent survival of T cells. However, IL-7 production is detectable in multiple organs and is not restricted to pLNs. This raises the question whether pLN-derived IL-7 is required for the maintenance of peripheral T cell homeostasis. Here, we show that numbers of naive T cells (TN ) remain unaffected in pLNs and spleen of mice lacking Il7 gene activity in pLN FRCs, LECs or both. In contrast, frequencies of central memory T cells (TCM ) are reduced in FRC-specific IL-7 knockout mice. Thus, steady state IL-7 production by pLN FRCs is critical for the maintenance of TCM , but not TN , indicating that both T cell subsets colonize different ecological niches in vivo. This article is protected by copyright. All rights reserved.
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Eur J Immunol. 2020 Feb 11. doi: 10.1002/eji.201948368.
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en
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1521-4141
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Attribution-NonCommercial-ShareAlike 4.0 International