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Solid Phase Extraction as an Innovative Separation Method for Measuring Free and Entrapped Drug in Lipid Nanoparticles.

Guillot, Alexis
; 
Couffin, Anne-Claude
; 
Sejean, Xavier
; 
Navarro, Fabrice
; 
Limberger, Markus
; 
Lehr, Claus-Michael
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Issue Date
2015-12
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original manuscript with figures
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Abstract
Contrary to physical characterization techniques for nanopharmaceuticals (shape, size and zeta-potential), the techniques to quantify the free and the entrapped drug remain very few and difficult to transpose in routine analytical laboratories. The application of Solid Phase Extraction (SPE) technique was investigated to overcome this challenge.
Citation
Solid Phase Extraction as an Innovative Separation Method for Measuring Free and Entrapped Drug in Lipid Nanoparticles. 2015, 32 (12):3999-4009 Pharm. Res.
Affiliation
Helmholtz Institute for Pharmaceutical Research Saarland (HIPS);Saarland University, Building A4.1, 66123 Saarbruecken, Germany.
Publisher
Journal
Pharmaceutical research
URI
http://hdl.handle.net/10033/595966
DOI
10.1007/s11095-015-1761-8
PubMed ID
26202518
PubMed Central ID
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Article
Language
en
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ISSN
1573-904X
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publications of the research group drug delivery ([HIPS] DDEL)