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The relative composition of the inflammatory infiltrate as an additional tool for synovial tissue classification.

Della Beffa, Cristina
; 
Slansky, Elisabeth
; ; ; 
Li, Jialiang
; 
Dai, Lie
; 
Schumacher, H Ralph
; 
Pessler, Frank
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2013
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Abstract
Traditionally, differences in absolute numbers of cells expressing a certain marker (e.g., positive staining cells per mm(2)) have been used in immunohistological synovial tissue classification. We have begun to evaluate the relative composition of the inflammatory infiltrates, i.e. percentages of inflammatory cell types in inflammatory infiltrates, as an alternate classification tool that may potentially improve tissue diagnostics, subgrouping in clinical trials, and understanding of pathogenesis of inflammatory and noninflammatory arthropathies.
Citation
The relative composition of the inflammatory infiltrate as an additional tool for synovial tissue classification. 2013, 8 (8):e72494 PLoS ONE
Affiliation
Department of Cellular Proteomics, Helmholtz Centre for Infection Research, Braunschweig, Germany.
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PloS one
URI
http://hdl.handle.net/10033/300668
DOI
10.1371/journal.pone.0072494
PubMed ID
23951325
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Article
Language
en
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1932-6203
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publications of the research group cellular proteom research (CPRO)