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Covalent Lectin Inhibition and Application in Bacterial Biofilm Imaging.

Wagner, Stefanie
; 
Hauck, Dirk
; 
Hoffmann, Michael
; 
Sommer, Roman
; 
Joachim, Ines
; ; 
Imberty, Anne
; 
Varrot, Annabelle
; 
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Issue Date
2017-09-28
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Abstract
Biofilm formation by pathogenic bacteria is a hallmark of chronic infections. In many cases, lectins play key roles in establishing biofilms. The pathogen Pseudomonas aeruginosa often exhibiting various drug resistances employs its lectins LecA and LecB as virulence factors and biofilm building blocks. Therefore, inhibition of the function of these proteins is thought to have potential in developing "pathoblockers" preventing biofilm formation and virulence. A covalent lectin inhibitor specific to a carbohydrate binding site is described for the first time. Its application in the LecA-specific in vitro imaging of biofilms formed by P. aeruginosa is also reported.
Citation
Covalent Lectin Inhibition and Application in Bacterial Biofilm Imaging. 2017 Angew. Chem. Int. Ed. Engl.
Affiliation
HIPS, Helmholtz-Institut für pharmazeutische Forchung Saarland, Universitätscampus E8.1, 66123 Saarbrücken, Germany.
Publisher
Journal
Angewandte Chemie (International ed. in English)
URI
http://hdl.handle.net/10033/621212
DOI
10.1002/anie.201709368
PubMed ID
28960731
PubMed Central ID
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Article
Language
en
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ISSN
1521-3773
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publications of the junior research group chemical biology of carbohydrates ([HIPS]CBCH)
publications of the research group of microbial natural substances([HIPS]MINS)