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Total Synthesis of Nannocystin Ax.
Poock, Caroline Kalesse, Markus
Poock, Caroline
Kalesse, Markus
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2017-09-01
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Abstract
The total synthesis of nannocystin Ax in an overall yield of 11% with 14 steps as the longest linear sequence is reported. Nannocystin Ax is a cytotoxic 21-membered depsipeptide and was isolated from the myxobacterial genus Nannocystis sp. The synthesis uses a vinylogous Horner-Wadsworth-Emmons reaction (HWE) and a vinylogous Mukaiyama aldol reaction (VMAR) as the key steps for the construction of the polyketide fragment. The macrocycle was closed via a macrolactamization reaction using COMU.
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Total Synthesis of Nannocystin Ax. 2017, 19 (17):4536-4539 Org. Lett.
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en
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1523-7052