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The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB.
Formicola, Beatrice Dal Magro, Roberta Montefusco-Pereira, Carlos V Lehr, Claus-Michael Koch, Marcus Russo, Laura Grasso, Gianvito Deriu, Marco A Danani, Andrea Bourdoulous, Sandrine
Formicola, Beatrice
Dal Magro, Roberta
Montefusco-Pereira, Carlos V
Lehr, Claus-Michael
Koch, Marcus
Russo, Laura
Grasso, Gianvito
Deriu, Marco A
Danani, Andrea
Bourdoulous, Sandrine
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2019-11-11
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Abstract
We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood-brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes.
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J Nanobiotechnology. 2019 Nov 11;17(1):115. doi: 10.1186/s12951-019-0546-3.
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en
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1477-3155
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Attribution-NonCommercial-ShareAlike 4.0 International