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Structurally diverse metabolites from the rare actinobacterium Saccharothrix xinjiangensis.

Babadi, Zahra Khosravi
; 
Sudarman, Enge
; 
Ebrahimipour, Gholam Hossein
; 
Primahana, Gian
; ; 
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Issue Date
2019-08-26
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Abstract
The bioassay-guided fractionation from cultures of the actinobacterium Saccharothrix xinjiangensis Act24Zk, collected from the Caspian Sea beach in Iran led to the isolation of three new compounds, caerulomycin M (1), saccharopyrone (2), and saccharonoic acid (3), together with the known compound, caerulomycin A (4). Their structures were elucidated from HR-ESIMS and 1D and 2D NMR data. Compound 2 displayed moderate cytotoxic activity against the human cervix carcinoma HeLa cells KB3.1 with an IC50 value of 5.4 µM.
Citation
J Antibiot (Tokyo). 2019 Aug 26. pii: 10.1038/s41429-019-0223-7. doi: 10.1038/s41429-019-0223-7.
Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.
Publisher
Japan Antibiotics Research Association
Journal
The journal of Antibiotics
URI
http://hdl.handle.net/10033/621966
DOI
10.1038/s41429-019-0223-7
PubMed ID
31451754
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Article
Language
en
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ISSN
0021-8820
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Attribution-NonCommercial-ShareAlike 4.0 International
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publications of the research group microbial strain collection(MISG)
publications of the research group of microbial drugs (MWIS)