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Expression of S100A8/A9 in HaCaT keratinocytes alters the rate of cell proliferation and differentiation.
Voss, Andreas Bode, Günther Sopalla, Claudia Benedyk, Malgorzata Varga, Georg Böhm, Markus Nacken, Wolfgang Kerkhoff, Claus
Voss, Andreas
Bode, Günther
Sopalla, Claudia
Benedyk, Malgorzata
Varga, Georg
Böhm, Markus
Nacken, Wolfgang
Kerkhoff, Claus
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2011-01-21
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Abstract
S100A8/A9 promotes NADPH oxidase in HaCaT keratinocytes and subsequently increases NFκB activation, which plays important roles in the balance between epidermal growth and differentiation. S100A8/A9-positive HaCaT cells present with a significantly reduced rate of cell division and greater expression of two keratinocyte differentiation markers, involucrin and filaggrin, than control cells. S100A8/A9 mutants fail to enhance NFκB activation, TNFα-induced IL-8 gene expression and NFκB p65 phosphorylation, and S100A8/A9-positive cells demonstrate better cell survival in forced suspension culture than mutant cells. S100A8/A9 is induced in epithelial cells in response to stress. Therefore, S100A8/A9-mediated growth arrest could have implications for tissue remodeling and repair.
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Expression of S100A8/A9 in HaCaT keratinocytes alters the rate of cell proliferation and differentiation. 2011, 585 (2):440-6 FEBS Lett.
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en
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1873-3468