Loading...
Soluble immune markers in the different phases of chronic hepatitis B virus infection
Wiegand, Steffen B. Wiegand, S. Beggel, Bastian Wranke, Anika Aliabadi, Elmira Jaroszewicz, Jerzy Xu, Cheng Jian Li, Yang Manns, Michael P. Lengauer, Thomas
Wiegand, Steffen B.
Wiegand, S.
Beggel, Bastian
Wranke, Anika
Aliabadi, Elmira
Jaroszewicz, Jerzy
Xu, Cheng Jian
Li, Yang
Manns, Michael P.
Lengauer, Thomas
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
2019-10-01
Submitted date
Files
Loading...
Open Access publication
Adobe PDF, 2.43 MB
Other Titles
Abstract
Chronic hepatitis B virus (HBV) infection may follow four different consecutive phases, which are defined by virology as well as biochemical markers and differ in terms of prognosis and need for antiviral treatment. Currently, host responses reflected by immune markers are not considered in this definition. We aimed to study soluble immune markers and their distribution in different phases of chronic HBV infection. In this cross-sectional retrospective study, we investigated a panel of 14 soluble immune markers (SIM) including CXCL10 in 333 patients with chronic HBV infection. In a small cohort of HBeAg positive patients we analyzed SIM before and after HBeAg seroconversion and compared seroconverters to patients with unknown outcome. Significant differences were documented in the levels of several SIM between the four phases of chronic HBV infection. The most pronounced difference among all investigated SIM was observed for CXCL10 concentrations with highest levels in patients with hepatitis. TGF-β and IL-17 revealed different levels between HBeAg negative patients. HBeAg positive patients with HBeAg seroconversion presented higher amounts of IL-12 before seroconversion compared to HBeAg positive patients with unknown follow up. SIM such as CXCL10 but also IL-12, TGF-β and IL-17 may be useful markers to further characterize the phase of chronic HBV infection.
Citation
Sci Rep. 2019 Oct 1;9(1):14118. doi: 10.1038/s41598-019-50729-5.
Publisher
Journal
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Article
Language
en
Description
Series/Report no.
1
ISSN
EISSN
ISBN
ISMN
Gov't Doc #
Sponsors
License
Attribution-NonCommercial-ShareAlike 4.0 International