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Bacteria in Cancer Therapy: Renaissance of an Old Concept.
Felgner, Sebastian Kocijancic, Dino Frahm, Michael Weiss, Siegfried
Felgner, Sebastian
Kocijancic, Dino
Frahm, Michael
Weiss, Siegfried
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Abstract
The rising incidence of cancer cases worldwide generates an urgent need of novel treatment options. Applying bacteria may represent a valuable therapeutic variant that is intensively investigated nowadays. Interestingly, the idea to apply bacteria wittingly or unwittingly dates back to ancient times and was revived in the 19th century mainly by the pioneer William Coley. This review summarizes and compares the results of the past 150 years in bacteria mediated tumor therapy from preclinical to clinical studies. Lessons we have learned from the past provide a solid foundation on which to base future efforts. In this regard, several perspectives are discussed by which bacteria in addition to their intrinsic antitumor effect can be used as vector systems that shuttle therapeutic compounds into the tumor. Strategic solutions like these provide a sound and more apt exploitation of bacteria that may overcome limitations of conventional therapies.
Citation
Bacteria in Cancer Therapy: Renaissance of an Old Concept. 2016, 2016:8451728 Int J Microbiol
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PubMed Central ID
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Article
Language
en
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Series/Report no.
ISSN
1687-918X