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2020-10-08
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Abstract
Cytomegaloviruses (CMV) coevolve with their hosts and latently persist in the vast majority of adult mammals. Therefore, persistent T-cell responses to CMV antigens during virus latency offer a fascinating perspective on the evolution of the T-cell repertoire in natural settings. We addressed here the life-long interactions between CMV antigens presented on MHC-I molecules and the CD8 T-cell response. We present the mechanistic evidence from the murine model of CMV infection and put it in context of clinical laboratory results. We will highlight the remarkable parallels in T-cell responses between the two biological systems, and focus in particular on memory inflation as a result of competitive processes, both between viral antigenic peptides and between T-cell receptors on the host’s cytotoxic lymphocytes
Citation
Curr Opin Virol. 2020 Oct 8;44:162-168. doi: 10.1016/j.coviro.2020.08.007.
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en
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1879-6265
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Attribution-NonCommercial-ShareAlike 4.0 International