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Effect of beta-blocker therapy on the risk of infections and death after acute stroke--a historical cohort study.

Maier, Ilko L
; 
Karch, André
; 
Mikolajczyk, Rafael
; 
Bähr, Mathias
; 
Liman, Jan
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2015
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Abstract
Infections are a frequent cause for prolonged hospitalization and increased mortality after stroke. Recent studies revealed a stroke-induced depression of the peripheral immune system associated with an increased susceptibility for infections. In a mice model for stroke, this immunosuppressive effect was reversible after beta-blocker administration. The aim of our study was to investigate the effect of beta-blocker therapy on the risk of infections and death after stroke in humans.
Citation
Effect of beta-blocker therapy on the risk of infections and death after acute stroke--a historical cohort study. 2015, 10 (2):e0116836 PLoS ONE
Affiliation
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
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PloS one
URI
http://hdl.handle.net/10033/346873
DOI
10.1371/journal.pone.0116836
PubMed ID
25643360
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Article
Language
en
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1932-6203
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Publications of the AG (ESME)