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Zirconyl Clindamycinphosphate Antibiotic Nanocarriers for Targeting Intracellular Persisting

Heck, Joachim G.
; 
Rox, Katharina
; 
Lünsdorf, Heinrich
; 
Lückerath, Thorsten
; 
Klaassen, Nicole
; ; 
Goldmann, Oliver
; 
Feldmann, Claus
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[ZrO]2+[CLP]2– (CLP: clindamycinphosphate) inorganic–organic hybrid nanoparticles (IOH-NPs) represent a novel strategy to treat persisting, recurrent infections with multiresistant Staphylococcus aureus. [ZrO]2+[CLP]2– is prepared in water and contains the approved antibiotic with unprecedented high load (82 wt % CLP per nanoparticle). The IOH-NPs result in 70–150-times higher antibiotic concentrations at difficult-to-reach infection sites, offering new options for improved drug delivery for chronic and difficult-to-treat infections.
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Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
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http://hdl.handle.net/10033/621497
DOI
10.1021/acsomega.8b00637
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http://pubs.acs.org/doi/10.1021/acsomega.8b00637
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2470-1343
2470-1343
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Attribution-NonCommercial-ShareAlike 3.0 United States
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publications of the research group immunology of infection ([HZI]INI)