Loading...
Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria.
Hoffmann, Thomas Krug, Daniel Bozkurt, Nisa Duddela, Srikanth Jansen, Rolf Garcia, Ronald Gerth, Klaus Steinmetz, Heinrich
Hoffmann, Thomas
Krug, Daniel
Bozkurt, Nisa
Duddela, Srikanth
Jansen, Rolf
Garcia, Ronald
Gerth, Klaus
Steinmetz, Heinrich
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
2018-02-23
Submitted date
Files
Loading...
Open Access publication
Adobe PDF, 1.36 MB
Other Titles
Abstract
Some bacterial clades are important sources of novel bioactive natural products. Estimating the magnitude of chemical diversity available from such a resource is complicated by issues including cultivability, isolation bias and limited analytical data sets. Here we perform a systematic metabolite survey of ~2300 bacterial strains of the order Myxococcales, a well-established source of natural products, using mass spectrometry. Our analysis encompasses both known and previously unidentified metabolites detected under laboratory cultivation conditions, thereby enabling large-scale comparison of production profiles in relation to myxobacterial taxonomy. We find a correlation between taxonomic distance and the production of distinct secondary metabolite families, further supporting the idea that the chances of discovering novel metabolites are greater by examining strains from new genera rather than additional representatives within the same genus. In addition, we report the discovery and structure elucidation of rowithocin, a myxobacterial secondary metabolite featuring an uncommon phosphorylated polyketide scaffold.
Citation
Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria. 2018, 9 (1):803 Nat Commun
Publisher
Journal
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Article
Language
en
Description
Series/Report no.
ISSN
2041-1723