Loading...
Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1.
Kurhade, Chaitanya Zegenhagen, Loreen Weber, Elvira Nair, Sharmila Michaelsen-Preusse, Kristin Spanier, Julia Gekara, Nelson O Kröger, Andrea Överby, Anna K
Kurhade, Chaitanya
Zegenhagen, Loreen
Weber, Elvira
Nair, Sharmila
Michaelsen-Preusse, Kristin
Spanier, Julia
Gekara, Nelson O
Kröger, Andrea
Överby, Anna K
Files
Loading...
Open Access publication
Adobe PDF, 1.51 MB
Other Titles
Abstract
Although type I interferons (IFNs)-key effectors of antiviral innate immunity are known to be induced via different pattern recognition receptors (PRRs), the cellular source and the relative contribution of different PRRs in host protection against viral infection is often unclear. IPS-1 is a downstream adaptor for retinoid-inducible gene I (RIG-I)-like receptor signaling. In this study, we investigate the relative contribution of IPS-1 in the innate immune response in the different brain regions during infection with tick-borne encephalitis virus (TBEV), a flavivirus that causes a variety of severe symptoms like hemorrhagic fevers, encephalitis, and meningitis in the human host.
Citation
Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1. 2016, 13 (1):22 J Neuroinflammation
Publisher
Journal
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Article
Language
en
Description
Series/Report no.
ISSN
1742-2094