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Large-scale production of megakaryocytes in microcarrier-supported stirred suspension bioreactors.
Eicke, Dorothee Baigger, Anja Latham, Sharissa L Halloin, Caroline Zweigerdt, Robert Guzman, Carlos A Blasczyk, Rainer Figueiredo, Constança
Eicke, Dorothee
Baigger, Anja
Latham, Sharissa L
Halloin, Caroline
Zweigerdt, Robert
Guzman, Carlos A
Blasczyk, Rainer
Figueiredo, Constança
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2018-07-05
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Megakaryocytes (MKs) are the precursors of platelets (PLTs) and may be used for PLT production in vivo or in vitro, as well as a source for PLT-derived growth factors. Induced pluripotent stem cells represent an unlimited cell source for the in vitro production of MKs. This study aimed at developing an effective, xeno-free and scalable system to produce high numbers of MKs. In particular, microcarrier beads-assisted stirred bioreactors were evaluated as a means of improving MK yields. This method resulted in the production of 18.7 × 10
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en
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2045-2322
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Attribution-NonCommercial-ShareAlike 3.0 United States