Loading...
A Review of the Multipronged Attack of Herpes Simplex Virus 1 on the Host Transcriptional Machinery.
Hennig, Thomas Djakovic, Lara Dƶlken, Lars Whisnant, Adam W
Hennig, Thomas
Djakovic, Lara
Dƶlken, Lars
Whisnant, Adam W
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
2021-09-14
Submitted date
Files
Loading...
Open Access publication
Adobe PDF, 652.21 KB
Other Titles
Abstract
Autophagy is an evolutionary conserved catabolic pathway that ensures the degradation of intracellular components. The autophagic pathway is regulated by autophagy-related (Atg) proteins that govern formation of double-membraned vesicles called autophagosomes. Autophagy deficiency in regulatory T (Treg) cells leads to increased apoptosis of these cells and to the development of autoimmune disorders, predominantly characterized by intestinal inflammation. Recently, RORĪ³t-expressing Treg cells have been identified as key regulators of gut homeostasis, preventing intestinal immunopathology. To study the role of autophagy in RORĪ³t+ Foxp3+ Treg cells, we generated mice lacking the essential component of the core autophagy machinery Atg5 in Foxp3+ cells. Atg5 deficiency in Treg cells led to a predominant intestinal inflammation. While Atg5-deficient Treg cells were reduced in peripheral lymphoid organs, the intestinal RORĪ³t+ Foxp3+ subpopulation of Treg cells was most severely affected. Our data indicated that autophagy is essential to maintain the intestinal RORĪ³t+ Foxp3+ Treg population, thereby protecting the mice from gut inflammatory disorders.
Citation
Front Immunol. 2021 Aug 26;12:705436. doi: 10.3389/fimmu.2021.705436.
Publisher
Journal
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Article
Language
en
Description
Series/Report no.
ISSN
EISSN
1999-4915
ISBN
ISMN
Gov't Doc #
Sponsors
License
Attribution 4.0 International