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Mastering the Gram-negative bacterial barrier - Chemical approaches to increase bacterial bioavailability of antibiotics.
Ropponen, Henni-Karoliina Richter, Robert
Ropponen, Henni-Karoliina
Richter, Robert
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2021-03-08
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Abstract
To win the battle against resistant, pathogenic bacteria, novel classes of anti-infectives and targets are urgently needed. Bacterial uptake, distribution, metabolic and efflux pathways of antibiotics in Gram-negative bacteria determine what we here refer to as bacterial bioavailability. Understanding these mechanisms from a chemical perspective is essential for anti-infective activity and hence, drug discovery as well as drug delivery. A systematic and critical discussion of in bacterio, in vitro and in silico assays reveals that a sufficiently accurate holistic approach is still missing. We expect new findings based on Gram-negative bacterial bioavailability to guide future anti-infective research.
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Adv Drug Deliv Rev. 2021 May;172:339-360. doi: 10.1016/j.addr.2021.02.014. Epub 2021 Mar 8.
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Review
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en
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1872-8294
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Attribution-NonCommercial-NoDerivatives 4.0 International