Loading...
The impact of hepatitis B surface antigen on natural killer cells in patients with chronic hepatitis B virus infection.
Du, Yanqin Anastasiou, Olympia E Strunz, Benedikt Scheuten, Janina Bremer, Birgit Kraft, Anke Kleinsimglinhaus, Karolina Todt, Daniel Broering, Ruth Hardtke-Wolenski, Matthias
Du, Yanqin
Anastasiou, Olympia E
Strunz, Benedikt
Scheuten, Janina
Bremer, Birgit
Kraft, Anke
Kleinsimglinhaus, Karolina
Todt, Daniel
Broering, Ruth
Hardtke-Wolenski, Matthias
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
2021-04-01
Submitted date
Files
Loading...
Open Access publication
Adobe PDF, 2.86 MB
Other Titles
Abstract
Compared to the healthy controls, a reshaping of NK cell pool towards more CD56bright NK cells was observed during CHB infection. Importantly, NK cells in patients with low HBsAg levels (<100 IU/mL) displayed an activated phenotype with increased expression of activation makers CD38, granzyme B and proliferation marker Ki-67 while presenting with defective functional responses (MIP-1β, CD107a) at the same time. Furthermore, NK cell activation was negatively correlated with patient HBsAg levels while NK function correlated with patient age.
Citation
Liver Int. 2021 Apr 1. doi: 10.1111/liv.14885. Epub ahead of print.
Publisher
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Article
Language
en
Description
Series/Report no.
ISSN
EISSN
1478-3231
ISBN
ISMN
Gov't Doc #
Sponsors
License
Attribution 4.0 International