Thumbnail Image
Publication

The Role of Pulmonary and Systemic Immunosenescence in Acute Lung Injury.

Brandenberger, Christina
; 
Kling, Katharina Maria
; ; 
Christian, Mühlfeld
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
2018-08-01
Submitted date
Show all metadata
Files
Thumbnail Image
Open Access article
Adobe PDF, 1.36 MB
Other Titles
Abstract
Acute lung injury (ALI) is associated with increased morbidity and mortality in the elderly (> 65 years), but the knowledge about origin and effects of immunosenescence in ALI is limited. Here, we investigated the immune response at pulmonary, systemic and cellular level in young (2-3 months) and old (18-19 months) C57BL/6J mice to localize and characterize effects of immunosenescence in ALI. ALI was induced by intranasal lipopolysaccharide (LPS) application and the animals were sacrificed 24 or 72 h later. Pulmonary inflammation was investigated by analyzing histopathology, bronchoalveolar lavage fluid (BALF) cytometry and cytokine expression. Systemic serum cytokine expression, spleen lymphocyte populations and the gut microbiome were analyzed, as well as activation of alveolar and bone marrow derived macrophages (BMDM)
Citation
Affiliation
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Publisher
Journal
URI
http://hdl.handle.net/10033/621507
DOI
10.14336/AD.2017.0902
PubMed ID
30090646
PubMed Central ID
Additional Links
Embedded video
Type
Article
Language
Description
Series/Report no.
ISSN
2152-5250
EISSN
ISBN
ISMN
Gov't Doc #
Sponsors
License
Attribution-NonCommercial-ShareAlike 3.0 United States
cbn
Collections
publications of the work group microbial interactions and processes (MINP)