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Immune responses induced in cattle by vaccination with a recombinant adenovirus expressing Mycobacterial antigen 85A and Mycobacterium bovis BCG.

Vordermeier, H Martin
; 
Huygen, Kris
; 
Singh, Mahavir
; 
Hewinson, R Glyn
; 
Xing, Zhou
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2006-02-01
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Abstract
Cattle were vaccinated with an adenovirus expressing the mycobacterial antigen 85A (rAd85A), with Mycobacterium bovis BCG followed by rAd85A heterologous boosting, or with rAd85A followed by BCG boosting. BCG/rAd85A resulted in the highest direct gamma interferon responses. Cultured enzyme-linked immunospot assay analysis demonstrated that memory responses were induced by all three protocols but were strongest after BCG/rAd85A and rAd85A/BCG vaccination.
Citation
Infect. Immun. 2006, 74(2):1416-8
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URI
http://hdl.handle.net/10033/14555
DOI
10.1128/IAI.74.2.1416-1418.2006
PubMed ID
16428796
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Article
Language
en
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0019-9567
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publications of the research group genomeanalytics (GMAK)